Polynucleotides

Cellular Repair That Regenerates From Within

What It Is

Polynucleotides are injectable bio-stimulators made from purified DNA fragments. Unlike hyaluronic acid treatments that primarily hydrate, polynucleotides work at a cellular level, signalling your fibroblasts to produce new collagen and elastin while reducing inflammation and oxidative stress.

What It Does

Skin becomes firmer, more hydrated, and visibly healthier as the regenerative process takes hold over the weeks following treatment. Fine lines soften, texture improves, and overall tone becomes more even. The treatment also supports the skin’s natural defence against environmental damage.

The Approach

A typical course involves two to three sessions spaced two to four weeks apart, with maintenance sessions recommended every six months or so. The treatment is quick and requires no downtime. Dr Etok will tailor the plan to your skin’s specific condition and goals.

Are Polynucleotides Right For You?

Polynucleotides suit clients who want to improve their skin’s health and resilience at a deeper level. Ideal if you are noticing changes in texture, hydration, elasticity, or tone and want a regenerative approach rather than a cosmetic one. The treatment also works well for skin that has been compromised by sun damage, scarring, or inflammation. It suits those who value long-term skin quality over quick, surface-level results.

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THE TREATMENT PROCESS

Regenerative Science That Works With Your Biology

Polynucleotides are injected into the skin using a fine needle, targeting the areas where regeneration is most needed. The purified DNA fragments integrate with your tissue and begin signalling your cells to repair and renew. The process is straightforward and typically takes around 20 to 30 minutes. No anaesthetic is usually required, though one can be applied if preferred.

There is no significant downtime. You may notice mild redness or small bumps at the injection sites, which typically settle within 24 hours. Results develop gradually as your skin responds to the bio-stimulation, with most clients noticing visible improvements in texture, hydration, and firmness from around two to three weeks after treatment. Full results build cumulatively over the course of sessions.

A close-up image of a woman’s face, showing the area from cheek to temple. Her skin appears dewy and healthy, with visible pores and natural texture. Soft directional lighting highlights her cheekbone, eyebrow, and lips, creating a realistic, high-end beauty editorial look that celebrates real skin radiance.
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Answers to Common Questions About Your Treatment

Find helpful guidance on what to expect before and after your appointment. These answers are based on real questions from clients just like you.

Polynucleotides are purified fragments of DNA, typically derived from salmon or trout. These fragments are filtered, sterilised, and formulated into an injectable gel. Because their structure closely resembles human DNA, they are highly biocompatible and well-tolerated by the body. They have been used in regenerative medicine for over 30 years with an excellent safety profile.

Profhilo is a hyaluronic acid treatment that hydrates the skin and stimulates collagen through bio-remodelling. Polynucleotides take a different approach, working at a cellular level to signal repair, reduce inflammation, and stimulate fibroblast activity. They complement each other well, and Dr Etok may recommend using both as part of a phased treatment plan for comprehensive skin rejuvenation.

Most clients benefit from an initial course of two to three sessions spaced two to four weeks apart. After the initial course, maintenance treatments every six months help sustain the regenerative benefits. Dr Etok will assess your skin during consultation and recommend a plan based on your condition and goals.

Some clients notice an improvement in hydration and skin quality within the first couple of weeks. However, the deeper regenerative effects build over time as collagen and elastin production increases. Optimal results typically become apparent after completing the full course, with continued improvement in the weeks and months that follow.

There is no significant downtime. Mild redness, slight swelling, or small bumps at the injection sites may occur and usually resolve within 24 hours. Most clients return to their normal routine immediately after treatment. It is advisable to avoid intense exercise, direct sun exposure, and makeup for 24 hours.

The injections cause minimal discomfort. Most clients describe a light pricking sensation as the solution is delivered. The needles used are very fine, and the treatment is quick. A topical anaesthetic can be applied beforehand if you have a lower pain threshold, though most clients find it unnecessary.

Yes. Polynucleotides pair well with a wide range of treatments and can enhance their effects. They work particularly well alongside Profhilo for hydration, exosomes for cellular repair, microneedling for texture improvement, and NeoGen Plasma for comprehensive skin regeneration. Dr Etok will advise on the best combination and sequencing for your needs.

Polynucleotides are most commonly used on the face but are also highly effective on the neck, decolletage, hands, and the delicate area around the eyes. They are particularly valuable for skin that has been damaged by sun exposure, scarring, or inflammation, as their anti-inflammatory and regenerative properties support healing as well as rejuvenation.

Ready to Explore Polynucleotides?

Book a consultation to discuss whether polynucleotides suit your goals. Dr Etok will assess your skin’s condition, explain realistic outcomes for regeneration and repair, and recommend a treatment plan tailored to your needs.

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